Denosy® contains S-adenosylmethionine (SAMe), a precursor to the potent antioxidant Glutathione that protects hepatic cells from toxins and death. It is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function^3,4. Denosyl® may also be used in other areas of tissue oxidative injury caused by certain toxins or drugs which are related to reduced glutathione concentrations.⁴ Denosy®, however, goes beyond increasing glutathione levels and has been shown to protect liver cells from cell death and may be useful in cell regeneration.^1,5

• Aids in liver detoxification mechanisms in dogs and cats
• May be used in other areas of tissue oxidative injury and blood cell fragility caused by certain drugs
• May protect against negative effects on the liver caused by some medications
• Very high safety profile ^1,3,4
• Also, supports healthy brain function in senior dogs

The Liver

The liver is one of the largest organs in the body and performs many life-essential functions. It produces a vast number of hormones, enzymes, proteins, and other substances important for your pet’s life and well-being. It also detoxifies and removes waste products in the bloodstream by changing them to a form that can be eliminated. This filtering of waste products is important because toxins can damage the membranes of cells in the liver and other organs. The most important liver “detoxifier” is glutathione, a potent antioxidant and the liver’s first line of defense.

Antioxidant Therapy

Both dogs and cats make glutathione from S-adenosylmethionine (SAMe). SAMe is formed naturally by the liver from the amino acid methionine, found in your pet’s diet. When the liver is compromised, production of SAMe decreases resulting in less glutathione.1 This further compromises liver function. A study of dogs and cats with various liver function problems reported that many had low liver glutathione levels.²

Ingredients

Contains the active ingredient S-adenosylmethionine (SAMe) in an enteric coated tablet.

When to Use

PAW Denosyl® is used as adjunctive treatment for liver diseases or dysfunction, such as the following:

• Chronic hepatitis
• Hepatic lipidosis
• Cholangiohepatitis
• Paracetamol toxicity
• Corticosteroid use (Note: does not prevent corticosteroid-induced hepatic vacuolar change)
• Other acute or chronic hepatopathies, including hepatotoxins and neoplasia

Dosage & Administration

Absorption of Denosyl® is decreased when it is given with a meal. For optimal absorption, administer Denosyl® at least one hour before feeding your pet. For owners who find it difficult to administer tablets to their pets, Denosyl®tablet(s) may be disguised in a small bite of moist food. It is not necessary to withhold water from your pet when giving Denosyl®
In cats, tablets or capsules can “stick” in the throat instead of passing into the stomach. Therefore, cat owners should gently administer a small amount of water (ask your veterinarian for details) immediately following tablet administration to aid swallowing.
 
Denosyl® tablets should not be broken as the enteric coating of the Denosyl® tablet protects the active ingredient from destruction while in the stomach.
 
The number of tablets can be gradually reduced or increased at any time depending on the pet's needs. When increasing or decreasing the dose, adjustments should be done in full tablet increments.
 
Many pets are maintained long-term on every-other-day or every-third-day administration.

References

1. Center SA. Proceedings of the 18th ACVIM, Seattle, WA, 2000; 550-552.
2. Center SA. Proceedings of TNAVC, Orlando, FL 2001; 218-219.
3. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66(2):330-341.
4. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
5. Webster CRL, Boria P, Usechak P, Anwer MS. Vet Therapeutics 2002;3(4):474-484.
6. Center SA, Warner KL, Erb HN. Am J Vet Res 2002;63(8):1187-1197.